2016-03-23 · Here we report the development of stimuli-responsive clustered nanoparticles to systematically overcome these multiple barriers to cancer chemotherapy. The nanoparticles were constructed through molecular assembly of platinum (Pt) prodrug-conjugated poly(amidoamine)-graft-polycaprolactone (PCL-CDM-PAMAM/Pt) with PCL homopolymer and poly(ethylene glycol)- b -poly(ε-caprolactone) (PEG- b -PCL) copolymer ( Fig. 1 A and B ).

Apr 12, 2016 We developed a stimuli-responsive clustered nanoparticle (iCluster) and justified that its adaptive alterations of physicochemical properties (e.g. 

Such systems are able to control drug release by reacting to naturally occurring or external applied stimuli. Special attention is paid to the design and nanoparticle formulation of these so‐called smart drug‐delivery systems. Stimuli-responsive nanoparticles have been designed and studied, exploring their potentiality as self-assembled materials as building blocks for the development of "smart" materials for bio-applications. Perylene diimide derivatives (PDI) have been used as fluorogenic units and structural components of assembled high-brightness nanoparticles, where fluorescence changes can be triggered by Dual stimuli‐responsive nanoparticles capable of fine‐tuning drug release to augment therapeutic efficacy have become a promising tool for anticancer drug delivery. However, the rational design of these “smart” nanoparticles for a selective delivery and controlled release of multidrug combinations in cancer cells to achieve synergistic effects remain challenging. 2016-01-07 Stimuli-responsive nanoparticles would provide a universally applicable platform, with the cargoes playing important roles for MDR reversion.

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However, there are a series of biological barriers that impede nanomedicine from reaching target cells. This class of stimuli-responsive nanoparticles is inactive during blood circulation and under normal physiological conditions, but is activated by acidic pH, enzymatic up-regulation, or hypoxia once they extravasate into the tumor microenvironment. Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn 2+ in tumors. An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided.

A hurdle to this goal is the inherently unfavorable tumor penetration of nanoparticles due to their relatively large sizes. We developed a stimuli- responsive 

2016-01-07 Stimuli-responsive nanoparticles would provide a universally applicable platform, with the cargoes playing important roles for MDR reversion. To address the issue of tumor heterogeneity, neoantigens of specific tumors are required for screening for personalized therapy. 2019-03-04 Stimuli responsive nanoparticles systems are divided into 2 classes: internal (pH, enzyme, ROS, hypoxia, redox) and external (radiation, electromagnetic, thermal) stimuli depending upon the method of inducing the delivery of the drug (Figure 1) (Taghizadeh et al., 2015; Yao et al., 2016). Stimuli-Responsive Gold Nanoparticles for Cancer Diagnosis and Therapy.

The thermo-responsiveness and singlet oxygen generation of the loaded ICG in DMMA-modified PLL nanoparticles are comparable to those of free ICG under laser irradiation, which induces higher cytotoxicity to cancer cells compared to succinic anhydride (SA)-modified PLL nanoparticles that are not pH-responsive.

[ 48 ] developed a redox-responsive system for encapsulation of abscisic acid, a plant growth regulator responsible for regulating physiological changes in plants and increasing glutathione levels under stress Adapted with permission from ref. 30 (copyright 2015, American Chemical Society). (e) Reversible self-assembly of NPs controlled by a photoacid. Adapted with permission from ref. 31 (copyright 2015, Nature Publishing Group). - "Stimuli-responsive self-assembly of nanoparticles." We constructed a novel stimuli-responsive system, MSNPs 1, based on mechanized silica nanoparticles, in which mesoporous silica nanoparticles (MSNs) acted as nanocontainers to load cargo, and supramolecular switches consisting of hydrazone bond, azobenzene and α-cyclodextrin (α-CD) realized the controlled release of cargo molecules from MSNPs 1.

that external stimuli-responsive polymer P(MAA-co-NIPAM)-coating on MGNS acts as  However within 30 min of exposure to the differentiation stimulus, the HuR content More importantly only the DMARDs responsive patients (DAS <3.7 at the 6th nanoparticles in enhancing the aerobic microbial ability of sequencing batch  Stimuli-responsive self-assembly of nanoparticles 1. Solvents. Depending mostly on the ligand molecules bound to their surfaces, nanoparticles exhibit good solubility in 2. Acid/base.
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Stimuli-responsive nanoparticles would provide a universally applicable platform, with the cargoes playing important roles for MDR reversion. To address the issue of tumor heterogeneity, neoantigens of specific tumors are required for screening for personalized therapy.

The ability to design LNAs via nanoparticle encapsulation, decoration or bilayer-embedment offers a range of configurations with different structures and functions. Multifunctional hybrid porous silica nanoparticles for stimuli-responsive delivery of novel antimicrobial agents, Molecular and Nanoscale Physics, University of Leeds Stimuli-responsive polymeric nanoparticles have recently gained tremendous attention, in particular in the field of controlled drug delivery as a result of offering prolonged circulation times and on demand delivery.
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Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Folding driven self-assembly of a stimuli-responsive peptide-hyaluronan 

of nanoparticles typically relies on the formation of noncovalent. Stimuli responsive nanoparticles systems are divided into 2 classes: internal (pH, enzyme, ROS, hypoxia, redox) and external (radiation, electromagnetic, thermal) stimuli depending upon the method of inducing the delivery of the drug (Figure 1) (Taghizadeh et al., 2015; Yao et al., 2016). 2016-03-23 · Here we report the development of stimuli-responsive clustered nanoparticles to systematically overcome these multiple barriers to cancer chemotherapy. The nanoparticles were constructed through molecular assembly of platinum (Pt) prodrug-conjugated poly(amidoamine)-graft-polycaprolactone (PCL-CDM-PAMAM/Pt) with PCL homopolymer and poly(ethylene glycol)- b -poly(ε-caprolactone) (PEG- b -PCL) copolymer ( Fig. 1 A and B ). 2019-09-21 · Stimuli-responsive nanoparticles can be applied to soils in order to provide targeted and slow release of fertilizers, fungicides, herbicides, and plant growth regulators. Sun et al.

Stimuli-responsive polymeric nanoparticles have recently gained tremendous attention, in particular in the field of controlled drug delivery as a result of offering prolonged circulation times and on demand delivery.

In one example, the multiple stimuli- responsive nanocarriers could be discharged into small nanoparticles by responding to the low pH in tumor microenvironment, and then the platinum prodrugs in the small nanoparticles were activated by GSH for promoted penetrating and treating the poorly permeable pancreatic tumors . Polypeptide nanoparticles composed of thiol-modified polylysine (PLL) are cross-linked with disulfide bonds and modified with poly (ethylene glycol) (PEG) and pH-sheddable dimethylmaleic anhydride (DMMA), which exhibit reduction- and pH-responsiveness. 2013-10-23 · Nanoscale materials that deliver drugs in response to specific stimuli offer enhanced control of the drugs' release profile and distribution. This Review provides a comprehensive discussion of Stimuli-responsive nanoparticles have been designed and studied, exploring their potentiality as self-assembled materials as building blocks for the development of "smart" materials for bio-applications.

2011-06-11 · Specifically, LNAs can be used to concentrate and shield the nanoparticles and, in turn, stimuli-responsive nanoparticles that respond to external fields can be used to control liposomal release. The ability to design LNAs via nanoparticle encapsulation, decoration or bilayer-embedment offers a range of configurations with different structures and functions. Multifunctional hybrid porous silica nanoparticles for stimuli-responsive delivery of novel antimicrobial agents, Molecular and Nanoscale Physics, University of Leeds Stimuli-responsive polymeric nanoparticles have recently gained tremendous attention, in particular in the field of controlled drug delivery as a result of offering prolonged circulation times and on demand delivery. Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy Rania M. Hathout 1, AbdelKader A. Metwally 1, Sherweit H. El-Ahmady 2, Eman S. Metwally 3, Noha A. Ghonim 3, Salma A. Bayoumy 3, Tarek Erfan 3, Rosaline Ashraf 3, Maha Fadel 4, Abdullah I. El-Kholy 4 and John G. Hardy 5,6 Stimuli-responsive co-delivery of oligonucleotides and drugs by self-assembled peptide nanoparticles Severin J. Sigg, Viktoriia Postupalenko, Jason T. Duskey, Cornelia G. Palivan, Wolfgang Meier* Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland KEYWORDS (2019).